| abstract |
PCT No. PCT/GB90/02003 Sec. 371 Date Jun. 16, 1992 Sec. 102(e) Date Jun. 16, 1992 PCT Filed Dec. 21, 1990 PCT Pub. No. WO91/09947 PCT Pub. Date Jul. 11, 1991.A serine protease inhibitor, similar in some respects to alpha 1-antitrypsin (AAT) but having an unglycosylated molecular weight on PAGE of 32+/-1 kDa, has been discovered. cDNA encoding the active protein has been cloned and sequenced, so the sequence of the protein has been revealed. Recombinant DNA technology enables the natural polypeptide sequence and related proteins to be prepared, for example by expression in E. coli. The inhibitor may prove useful in the treatment of emphysema, arthritis or septic shock. |