| abstract |
The novel 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivertives of the formula (I): <IMAGE> (I) wherein, R0, R1 and R2 are the same or different and represent a hydrogen atom or a lower alkyl group; A represents a formula: <IMAGE> wherein, X stands for a chemical bond or a formula: <IMAGE> (wherein, X' stands for a chemical bond or an alkylene group having 1 to 5 carbon atoms which may contain sulfur or oxygen atom as the constituent atoms, R5 and R6 are the same or different and stand for a hydrogen atom or a lower alkyl group), R3 stands for an aromatic heterocyclic group which may be substituted, n denotes 0, 1 or 2), and R4 stands for a hydrogen atom or an alkanoyl group, or a physiologically acceptable salt thereof have antifungal activities, and they are used for preventing or treating infectious diseases caused by fungi. |