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publicationDate 1995-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5403848-A
titleOfInvention Diagnosis and treatment of a disorder of the gastrointestinal tract
abstract Cyproheptadine (4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterized by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.
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