| abstract |
Phenylethanolamino- and phenylethanolaminomethyltetralines of formula (I) ##STR1## wherein X represents a hydrogen atom, a halogen atom, a (C 1 -C 4 )alkyl group or a trifluoromethyl group, n A represents a bond between the --COOR group and the tetraline ring, a (C 1 -C 4 )alkylene or a (C 2 -C 4 )alkenylene group, n R is hydrogen or a (C 1 -C 4 )alkyl group, and n n is 0 or 1 n and their salts, are typically prepared by reaction of an epoxide of formula (IIa) ##STR2## with a tetraline derivative of formula (III) ##STR3## wherein A and n are as defined above and R' is a (C 1 -C 4 )alkyl group, optionally followed by basic hydrolysis to obtain the compounds (I) wherein R is hydrogen. The new compounds show very interesting properties as antidepressant and intestinal spasmolytic agents. n The new intermediates of formula (III) are also claimed. |