| abstract |
The invention relates to Δ 8 - and Δ 9 -prostaglandin derivatives of formula I, ##STR1## in which means the radicals or , R 1 means ##STR2## COOR 4 or CONHR 5 , R 2 and R 3 respectively mean a hydrogen atom or a hydroxy group, and the OH group can be respectively in alpha- or beta- position, n means a CH 2 group, an O or S atom, n W means hydrogen, --OR 6 , halogen, --CN--, --NO 2 , trifluoromethyl or COOR 6 , and if R 4 means hydrogen, their salts with physiologically compatible bases, the alpha-, beta- or gamma- cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use. |