| abstract |
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound beta Gal(1-4) beta GlcNAc(1-3) beta Gal(1-4) beta GlcNAc-OR. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the beta Gal(1-4) beta GlcNAc (1-3) beta Gal (1-4) beta GlcNAc-OR compound. In this step, monofucosylation is achieved by use of the alpha (1-3)fucosyltransferase. |