| abstract |
A novel series of oxazole derivatives having the Formulae I and II <IMAGE> Formula I wherein R is H or C1-C5 lower alkyl, X is N or CH, Y is H or CO2R1, or CO.R2, provided that when X is CH, Y is not H, R1 is C1-C5 lower alkyl, or phenylmethyl, and R2 is C1-C5 alkyl; <IMAGE> Formula II wherein R is H or C1-C5 lower alkyl, X is (CH2)n or para or meta substituted phenyl wherein the substituent is OR2, R2 is C1-C5 alkyl, and n is an integer of 4 to 8, or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of ADP-induced blood platelet aggregation in human platelet-rich plasma. |