| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a6a9431aa1fe5109ca95ad4e332231b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16722
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-948
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16721 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate |
1992-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c91803ad4d306c68b28c5ead460e34e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bdc346ca88d84daf4746e5ff2b15dc7 |
| publicationDate |
1994-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5352596-A |
| titleOfInvention |
Pseudorabies virus deletion mutants involving the EPO and LLT genes |
| abstract |
An attenuated pseudorabies virus (PRV) having a reduced ability to reactivate from latency is produced by introducing (1) a genomic modification in the early protein 0 (EP0) gene whereby said virus is characterized by the inability to express the early protein 0; or (2) a genomic modification in the large latency transcript (LLT) gene whereby said virus is characterized by disruption of the synthesis of said large latency transcript; or (3) the genomic modifications described in both (1) and (2). The attenuated virus is useful in a vaccine for psuedorabies-susceptible animals, particularly swine. Swine vaccinated with a deletion mutant in the EP0/LLT overlap region displayed reduced virus shedding and fewer clinical signs than animals inoculated with a wild type virus. The deletion mutant-vaccinated swine also harbored less PRV DNA in the nervous tissue and showed reduced ability to reactivate the virus. |
| isCitedBy |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008262198-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002177609-A1 |
| priorityDate |
1992-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |