http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5348878-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-163 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-16 |
| filingDate | 1991-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1326f9bf9b46756da80fa82357ab35fe |
| publicationDate | 1994-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5348878-A |
| titleOfInvention | Class I MHC-restricted T-T hybridomas, and a CD8-transfected BW5147, fusion partner therefor |
| abstract | The present invention provides class I MHC-restricted T-T hybridomas, a novel T-T fusion partner therefor and an assay system that allows for the generation and detection of functional, class I MHC restricted T-T hybridomas. The fusion partner comprises a murine BW5147 cell line that has been transfected with a CD8 gene and stably expresses the CD8 gene product. The BW5147 transfectants are used to generate functional, class I MHC restricted T-T hybridomas which are permissive for lymphokine production. Functional class I MHC-restricted T-T hybridomas exhibiting the capability of producing lymphokines are prepared by fusing BW5147 cells expressing CD8 with T lymphocytes activated in a mixed leukocyte reaction (alloreactive T cells) or stimulated with antigen (antigen-stimulated T lymphocytes) and screening the resulting hybrids for the ability to produce lymphokines in response to appropriate antigenic stimulation. Responsiveness of these clones to alloantigen or to antigen-MHC I complexes can be tested by measuring their production of lymphokines, which provides a sensitive and quantitative assay system. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11043823-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007141704-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6652848-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005169898-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7601342-B2 |
| priorityDate | 1990-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 288.