| abstract |
There are presented antibacterial cephalosporins having broad antimicrobial activity as well as intermediates for their formation, such compounds having the formula <IMAGE> I wherein R is hydrogen or a carboxylic acid-protecting group; R1 is a substituted piperazinium group of the formula <IMAGE> in which Q represents a substituted quinolinyl or naphthyridinyl group and the piperazine nucleus may be optionally substituted with one or more lower alkyl groups; R2 is selected from the group consisting of hydrogen, lower alkoxy, lower alkylthio and amido; R3is hydrogen or an acyl group; and m is 0, 1 or 2, preferably 0; as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of these compounds. |