| abstract |
Compounds of the formula <IMAGE> I wherein R1, R2, R3, R4, R5, R6, R7, R8, n, m, o, p and q are as hereinafter set forth, and, when R2 is hydrogen, pharmaceutically acceptable salts thereof with bases, are described. The compounds of formula 1 are potent inhibitors of phospholipases A2 (PLA2's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury. |