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filingDate 1993-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1994-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1994-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5310952-A
titleOfInvention Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans
abstract A novel process for the preparation of aminochromans of the general formula: ##STR1## wherein R is a C 1 -C 4 alkyl group. In the process, a nitrochromanone of the general formula: ##STR2## is hydrogenated with hydrogen in the presence of a hydrogenation catalyst. The resultant aminochromanone (III) is reduced using zirconium oxide/isopropanol to the aminochromene (IV). The latter is finally hydrogenated with hydrogen in the presence of a hydrogenation catalyst to give the final product. The aminochromans are useful intermediates for the preparation of hypolipidaemic pharmaceuticals.
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