| abstract |
Novel 4-((alkyl or dialkyl)amino)quinolines are disclosed that are prepared by condensing 2-(trifluoromethyl)aniline or its derivative with an alkyl vinyl ketone, and alkyl ketone, an alkyl heteroaryl ketone or a cyclic ketone, to provide the corresponding ketimine, that is anionically cyclized to the quinoline. The quinolines are useful as intercalators of DNA, and also inhibit the replication of retroviruses, including HIV. |