| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b460b6e95e64228f98a7ffc6bde16de |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-09 |
| filingDate |
1992-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a836a784b885ec8e25b739b2faaa30c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d09edf5b9ab5780a31d6df0a204971d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2940299cd10c570658ff67ed2417530f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beced90256ad9659f7c707107c70ef05 |
| publicationDate |
1994-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5300660-A |
| titleOfInvention |
Efficient stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines and intermediates thereto |
| abstract |
Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity ##STR1## wherein R 1 is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH 2 ) m Ph wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group including n 1) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline n 2) aminolysis n 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R 2 is defined as R 1 above. ##STR2## |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1775347-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5801247-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1775347-A3 |
| priorityDate |
1986-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |