http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5298625-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3294 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate | 1992-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_116586a403439aa57e9ca3d9964ae782 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9445d1df74b841ddcbfb9c576845b309 |
| publicationDate | 1994-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5298625-A |
| titleOfInvention | Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-CoA reductase inhibitors |
| abstract | A process for the preparation of compounds of formula ##STR1## or salt thereof where R 1 is --X--Z and X is --C.tbd.C--, n R 2 and R 2 ' are independently hydrogen, alkyl or trialkylsilyl; n R 3 is hydrogen or alkyl; and n Z is a hydrophobic anchor; n which includes reacting a compound of formula ##STR2## where R 4 is alkyl, cycloalkyl or aryl; and R 5 is trialkylsilyl or triarylsilyl with a compound of formula ##STR3## where Y is a halogen, to form a compound of formula ##STR4## and hydrolyzing the compound of formula IV to obtain the compounds of formula I. Compounds of formula I or salt thereof where R 1 is --OR 2 ' may be prepared by reacting a compound of formula III with a compound of formula n n P(OR.sub.2).sub.3 XII. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009264656-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6958377-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005101788-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005085602-A1 |
| priorityDate | 1992-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 704.