| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0090b42619013c3d1519d626518860a6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-54 |
| filingDate |
1992-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85f5c271700a22260497e104aaf9e3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ad0ad917fa395e6dfebb47f05783cc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e201bfbb25e0a5911db598f9f4e45d |
| publicationDate |
1994-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5296232-A |
| titleOfInvention |
Pharmaceutical formulation which does not induce tolerance |
| abstract |
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004029959-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6284790-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001500885-A |
| priorityDate |
1989-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |