http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5292656-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 |
| filingDate | 1992-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4eec9fd53255a4e99a3e56d42974bfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4692c413cbecedd0e1a5f61a7498d0d7 |
| publicationDate | 1994-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5292656-A |
| titleOfInvention | Rat osteosarcoma cell line OSR-6 |
| abstract | The present invention relates to a novel cell line isolated from a rat osteosarcoma wherein the cell line has the following characteristics: a) normal p53 gene as compared to a non-tumorigenic Sprague-Dawley rat cell control; b) normal RB-1 gene as compared to a non-tumorigenic Sprague-Dawley rat cell control; c) a normal c-myc gene as compared to a non-tumorigenic Sprague-Dawley rat cell control; d) a normal c-fos gene as compared to a non-tumorigenic Sprague-Dawley rat cell control; e) a deregulated immediate early gene response; f) a canalicular network MATRIGEL(Trademark) growth pattern; g) tumorigenic in congenitally athymic mice; h) low levels of alkaline phosphatase activity; i) an ability to produce one or more of the following growth factors: 1) a nonheparin binding growth factor, 2) a first heparin binding growth factor, 3) a second heparin binding growth factor, 4) a third heparin binding growth factor, 5) a fourth heparin binding growth factor, 6) a fifth heparin binding growth factor, 7) a sixth heparin binding growth factor; and j) an ability to be serially propagated greater than sixty population doublings. The present invention also relates to growth factors having the characteristics of growth factors isolated from the rat osteosarcoma cell line. The present invention further relates to a process for producing such growth factors comprising growing the cells of the present invention in a culture medium and recovering the growth factors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9521918-A1 |
| priorityDate | 1992-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.