abstract |
A pyrroloquinoline compound of the following formula is disclosed: <IMAGE> wherein H, C1-6 alkyl, R1 is: <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein R is H, C1-10 alkyl, or C1-6 alkyloxycarbonyl; R2 is: H, C1-6 alkyl, <IMAGE> <IMAGE> <IMAGE> wherein R5 is C1-10 alkyl, aryl, or aryl C1-10 alkyl; R3 is: (CH2)nNHR wherein R is H, C1-6 alkyl, or C1-6 alkyloxycarbonyl; <IMAGE> <IMAGE> R4 is: H, C1-6 alkyl, C1-6 alkyloxycarbonyl, RCH2-, wherein R is H, C1-6 alkyl or aryl, or <IMAGE> X is O, or NR6 wherein R6 is equal to H or C1-6 alkyl and n is an integer from 1-3. The compounds of the invention exhibit bradykinin antagonist activity as well as activity with alpha -adrenergic, histaminergic, and muscarinic receptors. |