| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a6a9431aa1fe5109ca95ad4e332231b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 |
| filingDate |
1992-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88821b0caf760b6dd0e91976621dbec3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b4a6efdac964344062c9db59b1a61e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0abf8ce19e6c9b77230a573e8bb83ae8 |
| publicationDate |
1994-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5284834-A |
| titleOfInvention |
Adenosine functionalized congeners as cardiovascular treating agents for animals and methods for using same |
| abstract |
This invention comprises a series of N6-substituted adenosine analogues bearing functionalized chains for the covalent attachment to probes or solid supports. In these compounds coronary vasodilation in the open thorax dog model, typical of A2-adenosine receptor agonists, is shown. The potency is modulated by distal structural changes in the chain, with the highest A2-potency observed for two methylamides, a primary amine congener, and a biotin conjugate. These compounds have antihypertensive activity and certain components are charged and are excluded from crossing the blood-brain barrier. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7087589-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004098627-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518957-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7790735-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5547942-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006270629-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8153781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6316423-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5477857-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11396672-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5545627-A |
| priorityDate |
1985-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |