| abstract |
Oxazolyl derivatives of formula (I) <IMAGE> (I) wherein -A1=A2-A3=A4- represents a bivalent radical having the formula -CH=CH-CH=CH-(a-1), -N=CH-CH=CH-(a-2), -CH=N-CH=CH-(a-3), -CH=CH-N=CH-(a-4), -CH=CH-CH=N-(a-5), -N=CH-N=CH-(a-6) or -CH=N-CH=N-(a-7); R represents hydrogen or C1-4alkyl; R1 represents hydrogen, C1-6alkyl or hydroxyC1-6alkyl; m represents 1 or 2; D represents C1-4alkanediyl; B represents NR2, CH2, O, S, SO or SO2 wherein R2 is hydrogen or C1-4alkyl; n represents 0, 1 or 2; L represents hydrogen; C1-12alkyl; C3-6cycloalkyl; C3-6alkenyl optionally substituted with aryl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; arylcarbonyl; arylC1-6alkyloxycarbonyl; or a radical of formula -Alk-R3 (b-1); -Alk-Y-R4 (b-2); -Alk-Z1-C(=X)-Z2-R5 (b-3); or -CH2-CHOH-CH2-O-R6 (b-4), the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof have antiallergic properties. Compositions containing the same and methods of treating warm-blooded animals suffering from allergic diseases. |