| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_046375444296eaf6ccc2667a1c0d921c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-544
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-78 |
| filingDate |
1993-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54bb337aff264055b2fb0b7acd512a28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e55ae39aee4303e80f924727cb17414e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52b0fdf7e497ab381080509ad99cdc4 |
| publicationDate |
1994-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5278080-A |
| titleOfInvention |
Method for measuring the free fraction of ligands in biological fluids |
| abstract |
A one-step assay for the free portion of a ligand in a biological sample involves incubating a mixture of the sample with a labelled antibody for the ligand and a ligand analogue which competes with the ligand for binding to the antibody. The assay is characterized by choosing a ligand analogue which has a lower affinity for the antibody than does the ligand. An insolubilised ligand analogue preferably has a binding affinity for the antibody from 0.01% to 10% of that of the ligand. Ligand/ligand analogue pairs exemplified are T4/T3 (Thyroxine/Tri- iodothyronine); Testosterone/etiocholanol; and T3/T2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6143578-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5714336-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6159698-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8900882-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5449624-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5639670-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114544831-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6087088-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011136261-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5888835-A |
| priorityDate |
1988-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |