| abstract |
Compounds of the formulas <IMAGE> (1) or <IMAGE> (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are -(CH2)n- wherein n=3-5; R3 is H or alkyl (1-4C); R4 is a substituted or unsubstituted fused or conjugated bicycloaryl methylene; X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), aryl alkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine are useful for treating or preventing ulceration of tissue, especially cornea. |