| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate |
1989-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1993-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70ea7781a66493541cb1ac3fa51bd1b5 |
| publicationDate |
1993-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5264449-A |
| titleOfInvention |
N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone |
| abstract |
The present invention relates to new carbonyl 3R, 4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl] -2-pyrrolidinone derivatives carrying a carboxyester-type lipophilic moiety on the pyrrolidinone nitrogen. More particularly, the present invention concerns new N-substituted carbonyl-3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl) methyl]-2-pyrrolidinone derivatives of the formula (I): ##STR1## wherein R is an optionally substituted hydrocarbon group, and pharmaceutically acceptable acid addition salts thereof. n The new compounds of the formula (I) are potent ocular hypotensives that are valuable antiglaucoma agents. They are also targeted for use in the treatment of so-called dry eye. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-717298-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005070593-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5675038-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5463074-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5677327-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9736891-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5895645-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7132444-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5591426-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5675019-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104211638-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5453434-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5800807-A |
| priorityDate |
1989-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |