| abstract |
Azacyclic compounds selected from the group consisting of ##STR1## wherein R 1 is H or C 1-6 -alkyl n R 3 is ##STR2## wherein R' is C 3-8 -alkyl, cyclopropyl, C 4-8 -cycloalkyl, benzyl which may be substituted, or C 1-4 -alkoxy-C 1-4 -alkyl, and n R" is H or C 1-8 -alkyl or C 1-6 -alkoxy or C 1-4 -alkoxy-C 1-4 -alkyl or aryl, and n R'" is H or C 1-6 -alkyl or C 4-8 -cycloalkyl; and n R 4 is H, C 1-8 -alkyl or Cl; and ##STR3## provided that R 3 is not ##STR4## wherein R' is C 3-8 -alkyl, cyclopropyl or C 1-3 -alkoxymethyl, and provided that R 3 is not --CH═N--OR'", wherein R'" is H or C 1-6 -alkyl, when the compounds of formula I is ##STR5## and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease. |