| abstract |
A renin inhibiting compound of the formula: <IMAGE> wherein R0 is a mimic of the Phe-His dipeptide sequence of angiotensinogen which preceeds the renin cleavage site; R4 is loweralkyl, cycloalkylalkyl or arylalkyl; R5 is hydrogen, loweralkyl, hydroxyalkyl, loweralkenyl or formyl; R6 is -OH or -NH2; and D is <IMAGE> wherein R7 is hydrogen or loweralkyl and R8 is hydrogen, loweralkyl, hydroxyalkyl, alkoxyalkyl, thioalkoxyalkyl, haloalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylalkyl, loweralkenyl, alkynyl, aryl, arylalkyl, heterocyclic or heterocyclicalkyl; or R7 and R8 taken together -(CH2)n- wherein n is 3-6; and R9 is loweralkyl; or a pharmaceutically acceptable salt, ester or prodrug thereof. |