| abstract |
The invention provides new imidazole containing alkoxyimino derivatives of tetrahydronaphthalene and chroman of general formula (I) ##STR1## wherein Z is --CH 2 --or--O--; n m is an integer of 1 to 4; n n is zero of 1; n T is a straight or branched saturated C 1 -C 6 hydrocarbon chain or C 2 -C 5 alkenylene chain; n A is a bond or a divalent group consisting of --Si(R'R")--; --O--CH 2 --,--CF 2 --,C(R'R")--,vinylene or isopropenylene, wherein each of R' and R" being the same or different is hydrogen or C 1 -C 4 alkyl; n R is hydrogen or C 1 -C 4 alkyl; n R 1 and R 2 , being the same, are hydrogen or methyl, or one of R 1 and R 2 is hydrogen and the other is n a) a C 1 -C 8 alkyl group; n b) a C 5 -C 8 cycloalkyl or C 5 -C 8 cycloalkyl-C 1 C 4 alkyl group, wherein the cycloalkyl group or moiety is unsubstituted or substituted by 1 to 4 C 1 -C 4 alkyl groups; or n c) an aryl or aryl-C 1 -C 4 alkyl group, wherein the aryl group or the aryl moiety is unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, hydroxy, C 1 -C 4 alkyl, trihalo-C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio and C 1 -C 4 alkylsulfonyl; n R 3 is hydrogen or a substituent chosen from halogen, hydroxy, C 1 -C 4 alkyl, trihalo-C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio and C 1 -C 4 alkylsulfonyl; n R 4 is an --OR 5 or --N(R 5 R 6 ) group, wherein each of R 5 and R 6 independently is hydrogen, C 1 -C 6 alkyl, phenyl or benzyl; n and the pharmaceutically acceptable salts thereof, which are useful in the treatment of a disease state in which an enhancement of TxA 2 synthesis exerts a pathogenic effect. |