| abstract |
Muscle relaxant nitrogen bridge tetrahydroisoquinolines are disclosed. The novel compounds are represented by the formula ##STR1## wherein A is ##STR2## M represents --(CH 2 ) n --Z--(CH 2 ) n or ##STR3## R is a C 1-3 alkoxy group, or adjacent Rs are a methylenedioxy group, R 1 is lower alkyl; n is 1-6; n m is 2 or 3; p is 1-3; Z is --N + (R 2 R 3 )--, --N(R 4 )--, ##STR4## and --N[(CH 2 ) n --A--R 5 ]--; R 2 and R 3 are independently lower alkyl groups wherein a carbon atom within the chain may be replaced by a heteroatom, lower cycloalkyl, lower cycloalkyl lower alkyl, aryl, aryl lower alkyl, a 4- to 6-member heteroring or may be combined with the nitrogen to form a heteroring; R 4 is a straight- or branched- chain C 1-10 alkyl wherein a carbon atom within the chain may be replaced by a heteroatom, lower cycloalkyl, lower cycloalkyl lower alkyl, aryl, or a heteroring, which groups may be substituted or unsubstituted; or ##STR5## R 5 is lower alkyl or lower alkenyl; Y is hydrogen, lower alkyl wherein a carbon atom within the chain may be replaced by a heteroatom, lower alkoxy, aryl, aryloxy, lower cycloalkyl, lower cycloalkyl lower alkyl, a 4- to 6-member heteroring or --NR 2 R 3 ; X - is a pharmaceutically acceptable anion, and optically active forms thereof, meso forms thereof, cis-trans isomeric forms thereof and racemates thereof. |