http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5229420-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 |
| filingDate | 1991-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71be0e7597065b65410354ec5439d26f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22f0df95f2b38d643eebc6f76abbdfe |
| publicationDate | 1993-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5229420-A |
| titleOfInvention | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents |
| abstract | Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are of the formula <IMAGE> wherein X is selected from oxygen atom and methylene; wherein R1 is selected from methyl, ethyl, t-butyloxycarbonyl and 2-(N-piperidinyl)ethyl; wherein R2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R3 is selected from benzyl, phenethyl, pyridylmethyl and 2-pyridylethyl; wherein each of R4 and R6 is independently selected from hydrido and methyl; wherein R7 is cyclohexylmethyl; wherein R8 is isobutyl; wherein each of R9 and R11 is hydrido; wherein m is zero or one and n is a number selected from zero through five; or a pharmaceutically-acceptable salt thereof; with the proviso that where m is zero, then R5 is selected from imidazolemethyl, thiazolemethyl and isobutyl; and with the further proviso that when m is one, then R5 is methyl or ethyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005080141-A1 |
| priorityDate | 1988-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 340.