| abstract |
Piperidine compounds having the formula <IMAGE> (1) wherein R3 is 3,4-methylenedioxyphenyl, phenyl, or naphthyl which are optionally substituted with one or more halogen, C1-6-alkoxy, or phenoxy, cyano, mono or poly halogenated C1-6-alkyl, C2-6-alkenyl, C1-6-alkyl, or C3-5-alkylene, R1 is straight or branched C1-8-alkyl substituted with piperidinyl morpholinyl thiomorpholinyl dioxolanyl or tetrahydrofuranyl, which heterocyclic radical is unsubstituted or C1-6-alkyl substituted, X is hydrogen, halogen, trifluoromethyl, hydroxy, cyano, or C1-8-alkoxy, Y is O or S; and pharmaceutically-acceptable acid addition salts thereof. The compounds are useful in the treatment of anoxia, migraine, ischemia, and epilepsy. |