http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5223403-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61C19-04 |
| filingDate | 1990-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e0b8e4de8f344e4d4cb247ddce94fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb82fe98849497fced0f39af811bb0ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc2709153f8a240b7bc583021da94bbd |
| publicationDate | 1993-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5223403-A |
| titleOfInvention | Device for diagnosing periodontal disease |
| abstract | A colorimetric assay system for diagnosing periodontal disease utilizes a chromogenic test substance for measuring proteolytic activity in a specimen such as subgingival plaque which may contain suspected periodontopathogenic bacteria. The chromogenic test substance comprises a peptide substrate which is hydrolyzable by proteolytic enzymes in the plaque specimen to release a chromophore. Detection of a color change in the test substance indicates whether such proteolytic activity is present. In a specific illustrative embodiment, the chromogenic test substance comprises N-benzoyl-DL-arginine-2-naphthylamide (BANA) or benzoyl-DL-arginine-p-nitroanilide (BAPNA). In the case of BANA, for example, the chromophore, beta -naphthylamide, is detected by the addition of a color developer, such as fast garnet. The development of a red-orange color is interpreted to indicate the presence of periodontal disease associated with anaerobic periodontopathogens, such as B. gingivalis, T. denticola, and B. forsythus, and the development of a yellow color is interpreted to indicate the absence of periodontal disease. The assay method can be carried out with a device having a first region containing on a support carrier a chromogenic test substance hydrolyzable by proteolytic enzymes of periodontopathogenic organisms to release a chromophore and a second region containing on a support carrier a color developer. The first and second regions are arranged so that they can be brought into superposition. The chromophore is released if the periodontopathogenic organisms exceed about 5x105 colony units. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6297024-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107860908-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6277587-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1037049-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220157110-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110042050-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0880602-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1037049-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6235494-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0880602-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6063588-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022245035-A1 |
| priorityDate | 1985-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.