http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5220053-A

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-487
filingDate 1992-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfcd23e3f2b4494ddb727aa348bec8db
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publicationDate 1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5220053-A
titleOfInvention Preparation of optically active aliphatic carboxylic acids
abstract An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding a mixture of the aliphatic carboxylic acid to the material formed by: (i) forming a solution comprising said racemic mixture of a C 1 to C 6 linear or branched aliphatic carboxylic acid and an organic or inorganic solvent; (ii) treating said solution with a chiral organic nitrogenous base; (iii) precipitating from the reaction solution formed in step (ii) a crystalline material comprised of the less soluble diastereomeric salt. The solution is admixed with the crystalline material for a time sufficient to cause an increase in the amount of the less soluble diastereomeric salt in the crystalline material.
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