http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5219883-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-58 |
| filingDate | 1991-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e2818ac26f3e2f1021d3cd524f5914d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a736f625976afd8461083bf1de87cd5f |
| publicationDate | 1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5219883-A |
| titleOfInvention | 2,2-di-substituted benzopyran leukotriene-D4 antagonists |
| abstract | This invention relates to LTD 4 antagonists of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein R 1 is methyl, phenyl, ##STR2## wherein X 1 and X 2 may be the same or different and are members of the group consisting of hydrogen, --Cl, --Br, --CF 3 , --NH 2 , --NO 2 , or alkyl of 1-3 carbon atoms; m is 1 to 9; n is 1 to 5; V is --CH(OH)--, or --CH 2 --; W is hydrogen or alkyl of 1-6 carbon atoms; Y is hydrogen or --COCH 3 provided that when W is hydrogen Y is not hydrogen; both Z moieties are --CHO, --COOR 2 , --COR 3 , --CH(OR 4 )--CH 2 OR 4 , or CH 2 OR 4 with the exception that when one Z moiety of Formula I is COOR 2 , the other Z moiety may be COR 3 ; n R 2 is hydrogen, a pharmaceutically acceptable cation, straight or branched chain alkyl having 1-6 carbon atoms, --CH 2 --CH(OR 5 )--CH 2 --OR 5 , CH(CH 2 OR 5 ) 2 with the proviso that when Z is --COOR 2 , the R 2 substituent in one --COOR 2 moiety may be the same or different from the R 2 substituent in the other COOR 2 moiety; n R 3 is --NR 7 R 8 wherein R 7 and R 8 may be the same or different and are members of the group comprising hydrogen or alkyl having 1-6 carbon atoms; n R 4 is hydrogen, or --C(O)--R 6 ; n R 5 is hydrogen, benzyl-, or alkyl or 1-3 carbon atoms; and n R 6 is alkyl of 1-6 carbon atoms. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7118747-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5457124-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009227603-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008194490-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005222044-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008293634-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7910555-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008008701-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8093253-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236761-B2 |
| priorityDate | 1988-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.