| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
1992-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1993-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dce389dcb078a0befab55f95f976653
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37489a60019e4712bfa25cb678a3714b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22f0df95f2b38d643eebc6f76abbdfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71be0e7597065b65410354ec5439d26f |
| publicationDate |
1993-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5217991-A |
| titleOfInvention |
Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
| abstract |
Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy beta -amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula <IMAGE> wherein R1 is selected from cycloalkyl and cycloalkylalkyl groups, wherein said cycloalkyl group contains three to about eight carbon atoms and the acyclic alkyl portion of said cycloalkylalkyl group contains one to about eight carbon atoms; wherein each of R2 and R4 is independently selected from hydrido and methyl; wherein R3 is methyl or ethyl: wherein R5 is cyclohexylmethyl; wherein R6 and R7 are taken together to form a partially saturated or fully saturated heterocyclic ring containing five to eight ring members with one or two ring members being oxygen atoms and the remaining ring members being carbon atoms, and which heterocyclic ring may be optionally substituted with lower alkyl; or a pharmaceutically-acceptable salt thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5326773-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9410137-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009069275-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006252825-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005080141-A1 |
| priorityDate |
1989-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |