| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23b7ff5765603f8b7cf29ab0ad584c47 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-721 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 |
| filingDate |
1991-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1993-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4361d5e04b4360372a11e84340634697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b07730dc92cf6ec7b7697e7c72748a9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_711027b9459d8bf83fec03efe8911db5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ea14ae75ee1fb877064a471c4c5ad90 |
| publicationDate |
1993-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5215916-A |
| titleOfInvention |
Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods |
| abstract |
The present invention relates to novel glucocorticoid receptors that have greater affinity and specifity for glucocorticoid steroids than the naturally occurring receptors. More particularly, the invention relates to the altering of the equivalent of cysteine-656 of the rat glucocorticoid receptor to either serine or glycine for the production of super glucocorticoid receptors which retain full biological activity in intact cells and have higher affinity and specificity for glucocorticoid steroid binding than the original receptor. The invention further relates to the recombinant expression of such altered receptors in host cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6599698-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2745008-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9731108-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6699686-B1 |
| priorityDate |
1991-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |