| abstract |
Compounds of the general formula ##STR1## Y is an integer of from 0 to 6 is chosen from: O, n SO 2 , n --CONH--, n --NHCO--, n --CH2-- or ##STR2## R 1 is substituted or unsubstituted mono- or polycyclic saturated hetero-cyclic ring system having 1, 2 or 3 heteroatoms where said heteroatoms are independently chosen from N, O and S and said substituents are chosen from the group comprising R 2 ; n R 2 is n C 1-6 alkyl, n aryl C 0-6 alkyl, n hydroxy C 0-6 alkyl, n C 1-6 alkoxy C 0-6 alkyl, n carboxy C 0-6 alkyl n oxo, n halogen, n CF 3 , n C 0-4 alkylamino-C 0-6 alkyl or n C 0-4 dialkylamino-C 0-6 alkyl; n R 3 is n C 1-8 alkyl or cycloalkyl, n aryl C 0-4 alkyl, n hydroxy C 0-4 alkyl n C 1-4 alkyloxy C 0-4 alkyl, n carboxy C 0-4 alkyl, n halogen, n CF 3 or n hydrogen; n R 4 is n hydrogen, n C 1-6 alkyl, n aryl C 0-4 alkyl or n C 1-6 alkylcarbonyloxymethyl; and n R 5 is n C 1-6 alkyl, n aryl C 0-4 alkyl or n heterocycly C 0-4 alkyl n and the pharmaceutically acceptable salts thereof; are used in a method of treating osteoporosis by inhibiting the bone resorption activity of osteoclasts. |