| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate |
1991-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1993-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5117f3a6810223108b4b0c8a69be8b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4696378e078a86ea0fd22442ccfbc5e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dab349910e6f722045c2728acd1df71b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c9f7f26ab4609a3a02faeeea538c26a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ea4716eaaea7f5958fb09d9b7c2444c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c3ebf5dcb40e342506490d159a3a33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b615590080b36a98c9cb04614811a4eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6029f7b48e79ae5007266cab36a69e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb7683dd38bcb87c6d82b5e51a69eaed |
| publicationDate |
1993-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5202443-A |
| titleOfInvention |
Process for preparing 1-(2s)-3-mercapto-methyl-1-oxopropyl)-l-proline |
| abstract |
The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). ##STR1## which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) ##STR2## in an inert solvent, in the presence of a catalyst, at a temperature of 50° to 120° C. under a pressure of 10 5 to 10 7 Pa. n The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). ##STR3## |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5276207-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5728887-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100507816-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1078206-C |
| priorityDate |
1990-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |