http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5196537-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 |
| filingDate | 1991-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6471ab0fdfb65cad09a79375edd331ba |
| publicationDate | 1993-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5196537-A |
| titleOfInvention | 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders |
| abstract | A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are antiotensin II antagonists of the formula ##STR1## wherein A is selected from ##STR2## wherein m is one; wherein R 1 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, benzyl, cyclohexyl, cyclohexylmethyl, 2-butenyl, 3-butenyl, 2-butynyl, 3-butynyl and 2-hydroxybutyl; wherein R 2 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neo-pentyl, 1-oxoethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl, 1,1-dimethoxypropyl, 1,1-dimethoxypentyl, halo, difluoromethyl, 1-oxo-2-phenylethyl, 1-oxo-2-cyclohexylethyl, 1,1-difluor-2-phenylethyl, 1,1-difluoro-2-cyclohexylethyl, 2-cyclohexylethyl, 1,1-difluoro-3-cyclohexylpropyl, 1,1-dimethoxybutyl, 1,1-difluoroethyl, 1,1-difluoropropyl, 1,1-difluorobutyl, 1,1-difluoropentyl, benzyl, 2-phenylethyl, 1,1-difluoro-3-phenylpropyl, cyclohexylmethyl, cyclohexanoyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-butynyl, 2-butynyl, 3-butynyl, propylthio and butylthio; wherein each of R 3 , R 4 , R 6 through R 11 is hydrido and R 5 is selected from COOH, SH, PO 3 H 2 , SO 3 H, CONHNH 2 , CONHNHSO 2 CF 3 , OH, ##STR3## wherein each of R 42 and R 43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013138352-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6211217-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3708179-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3241839-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2923706-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2810951-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2998314-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014197720-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5414003-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011069038-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5482951-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014151200-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014151206-A1 |
| priorityDate | 1991-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 3150.