http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5180840-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058e0be30e00d53858c67167df60aed5 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-18 |
filingDate | 1991-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1993-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75b319c1091103cb2a5fa0344366066c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16af82d2030ea7ebc180685d05378358 |
publicationDate | 1993-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-5180840-A |
titleOfInvention | Process for preparing analogs of artemisinin |
abstract | A process for synthesizing oxygen-containing polyoxatetracycle compounds and in particular analogs of the antimalarial agent known as qinghaosu or artemisinin is disclosed. The process employs as a reactant an olefinically unsaturated bicyclic bridging ketone having nonenolizable bridgehead moieties for both of its alpha positions. This ketone is converted to a vinylsilane that is subjected to ozonolytic cleavage of its olefinic bond to yield a member of a family of unique carboxyl/carbonyl-substituted vinylsilanes which may in turn optionally be subjected to a wide range of reactions prior to a final ozonolysis/acidification step which closes the oxygen-containing ring structure. The various intermediates are claimed as aspects of this invention as are novel tetracycles and their use as antimalarials. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9169291-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006128126-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007231300-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011150830-A1 |
priorityDate | 1986-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.