http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5177257-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79751aeaa9923745648e5ae7d9c35782 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C62-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-487 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-487 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C62-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| filingDate | 1991-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9111406a92e5284733f43c39efb0f797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8918994ef6960323f61ea19fdd0797d2 |
| publicationDate | 1993-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5177257-A |
| titleOfInvention | Benzocycloalkenecarboxylic acid and process for its preparation |
| abstract | PCT No. PCT/CH91/00064 Sec. 371 Date Nov. 20, 1991 Sec. 102(e) Date Nov. 20, 1991 PCT Filed Mar. 19, 1991 PCT Pub. No. WO91/14671 PCT Pub. Date Oct. 3, 1991.The novel (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic i.e. the compound of the formula <IMAGE> (I) in free form or in salt form, can be used as active ingredient in pharmaceutical preparations and can be prepared by a novel process, which is characterized in that racemic 4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is reacted at elevated temperature with at least the equimolar amount of quinine in an alcoholic solvent for from approximately 6 to approximately 48 hours, the quinine salt of the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid, precipitated in crystalline form as the direct reaction product, is separated from the reaction mixture, and the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is set free from this salt by acid treatment in a customary manner, and, if desired, this free acid is converted into a salt. |
| priorityDate | 1990-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.