http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5177211-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcf862c1ce80783d420cc1ffea924212 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 1991-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73776647f2608055c10dc305cde4f946 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f5d01ab9f4bf32fc4782494ebfd613f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2742fbc39d2841fb097bc175470a2108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d33f6eb3ccc09cd86ae0820a2b9969bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_798f7e14a5400dcadf766a7ea96cc04f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c203d5906047bccf91c517687e0431 |
| publicationDate | 1993-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5177211-A |
| titleOfInvention | 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity |
| abstract | 4-alkyl-1,4-dihyropyridines, with PAF-antagonist activity, of formula (I) wherein R is saturated C1-C4, R' is saturated C1-C6 alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R2 is saturated C1-C4 or phenyl, the compound wherein R is methyl, R' is ethyl and R2 is phenyl remain excluded, are described. The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor. <IMAGE> I <IMAGE> II <IMAGE> III <IMAGE> IV <IMAGE> V CH3COCH2COOR' VI RCHO VII CH3COCH2COO(CH2)2SR2 VIII |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6566359-B1 |
| priorityDate | 1988-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 291.