| abstract |
Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: <IMAGE> (1.0) and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension or a viral infection using compounds represented by Formulas 1.0. Also disclosed is a compound of Structure B <IMAGE> B useful as an intermediate in producing compounds of Formula 1.0. A process for preparing the compounds of Formula 1.0 is also disclosed. In the process a compound of Structure B <IMAGE> B is reacted with an alkoxide R1O-M+ in a solvent comprising the corresponding alcohol R1OH of the alkoxide. Optionally, an organic cosolvent may be used with the solvent. |