| abstract |
The present invention relates to anti-tumor-conjugation agent-protein compounds of the general formula I: <IMAGE> I wherein, R1 and R2 are each independently selected from hydrogen atom, C1-4alkyl, C1-4alkoxy, C1-6carboxyalkyl, phenyl, or phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, or nitro, with the proviso that R1 and R2 cannot be simultaneously a hydrogen, and when one of R1 or R2 is a hydrogen, the other one cannot be -CH2COOH; A is the residue of an anti-tumor agent containing at least one amino group available to form an amide bound; and B is a free epsilon -lysine containing residue selected from a peptide or a protein. |