http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5139491-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-557 |
| filingDate | 1990-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1992-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b578753f42206a467327bef2321577f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe9c84403569c4531f93ec276d4d3ed6 |
| publicationDate | 1992-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5139491-A |
| titleOfInvention | 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives |
| abstract | The present invention relates to 2-decarboxyl-2-alkoxyalkyl prostaglandins that are potent ocular hypotentives, and are particularly suitable for the management of glaucoma. Said 2-decarboxyl-2-alkoxyalkyl prostaglandins are compounds of the formula (I) <IMAGE> wherein the wavy line attachments indicate either alpha ( alpha ) or beta ( beta ) configuration; hatched lines indicate alpha configuration; solid triangles are used to indicate beta configuration; the dashed bonds represent a single bond or a double bond which can be in the cis or trans configuration; R is an aliphatic hydrocarbon group having from 1 to about 6 carbon atoms; one of R1 and R2 is=O, -OH or a -O(CO)R6 group, and the other one is -OH or a -O(CO)R6 group or R1 is=O and R2 is H, R3 is -OH or -O(CO)R6; R4 and R5 independently are hydrogen or an aliphatic hydrocarbon group having from 1 to about 6 carbon atoms; R6 is a saturated or unsturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or -(CH2)nR7 wherein n is 0-10, and R7 is an aliphatic ring from about 3 to about 7 carbon atoms or an aromatic or heteroaromatic ring; or a pharmaceutically acceptable salt of said compound. The invention also provides a pharmaceutical product including a container adapted to dispense an ophthalmic solution in metered form and containing said 2-decarboxyl-2-alkoxyalkyl prostaglandin in admixture with a non-toxic, ophthalmically acceptable liquid vehicle. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5288754-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5476872-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009082455-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6124353-A |
| priorityDate | 1990-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.