| abstract |
An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R 1 , R 2 , R 3 , and R 4 may be the same with or different from each other and are hydrogen, halogen, lower alkyl having 1 to 6 carbons, lower alkoxy having 1 to 6 carbons, acyl, substituted or unsubstituted amino, nitro, hydroxy, acyloxy, substituted or unsubstituted aralkyl, substituted or unsubstituted aryloxy, or substituted or unsubstituted aralkyloxy, or a combination of R 2 and R 3 may be methylenedioxy; n R 5 is hydrogen, lower alkyl having 1 to 6 carbons, or substituted or unsubstituted aralkyl; R and R 4 , or R 1 and R 5 may form together a six-membered ring constituted of methylene chains which may contain a heteroatom; n R 6 and R 7 may be the same with or different from each other and are hydrogen, lower alkyl having 1 to 6 carbons, or substituted or unsubstituted aryl or a five- or six-membered heterocyclic ring; n A is --COOR 8 (wherein R 8 is hydrogen, lower alkyl having 1 to 6 carbons, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl), or --CH 2 OR 9 (wherein R 9 is hydrogen, lower alkyl having 1 to 6 carbons, lower alkenyl having 2 to 6 carbons, acyl or substituted or substituted aralkyl); n and the method of producing the same, which comprises reacting, in the presence of a base, useful for hyperlipidemia and arteriosclerosis, is disclosed. |