| abstract |
PCT No. PCT/US90/00121 Sec. 371 Date Sep. 13, 1991 Sec. 102(e) Date Sep. 13, 1991 PCT Filed Jan. 12, 1990 PCT Pub. No. WO90/08315 PCT Pub. Date Jul. 26, 1990.Ginsenosides Rb1 and Rg1 enhance the availability of acetylcholine in the cortical and hippocampal regions of the brain and alleviaate the symptoms of Alzheimer-type senile dementia. The Rb1 or Rg1 may be administered together with a metabolic precursor for acetylcholine and/or with a cholinesterase inhibitor. Pure Rb1 is located from a mixture of ginsenosides by a process involving vacuum chromatography on silica gel. Preferably, the mixture of ginsenosides is enriched in Rb1 by partition between an aqueous system and water ethyl acetatebutanol. |