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filingDate 1991-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1992-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4effd4afcc87940e2b1e8dbbf4534276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_363fcd456e926366ba09fef251b2137e
publicationDate 1992-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5110928-A
titleOfInvention Preparation of n-aryl-substituted 2-aminoalkyl-2-hydroxyalkylamines and n-aryl-substituted piperazines
abstract N-Aryl-substituted 2-amino-alkyl-2-hydroxyalkylamines and N-aryl-substituted piperazines Ia and Ib respectively <IMAGE> (Ar=aryl; R1=hydrogen, methyl, identical or different, R2=hydrogen, alkyl) are prepared by reacting an N,N-di(2-hydroxyalkyl)-N-arylamine II <IMAGE> II with ammonia or a primary amine III H2N-R2 III at elevated temperature and under elevated pressure in the presence of hydrogen and of a catalyst which is a supported catalyst whose active mass predominantly contains copper and/or nickel and/or cobalt in the form of the metal or an oxide.
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