| abstract |
Intermediates of Formula ##STR1## where R is a methylthio, methylsulfoxy, methylsulfonyl or a nitro group; and n X1 is hydrogen, 1-6 C alkyl, 1-6 C haloalkyl, 3-6 C cycloalkyl, phenyl or phenylalkyl(1-6C), where the phenyl ring may be substituted by one or two halogen, 1-3 C alkyl, 1-3 C alkoxy or nitro; or n X1 together with X2 is an oxygen atom or an alkylene having from two to five Carbon atoms; or n X1 together with X2 and R4 is a chain of formula ##STR2## where p is 3 or 4 and q is 1 or 2; and X2 is hydrogen, 1-6 C alkyl, 1-6 C haloalkyl, 3-6 C cycloalkyl or phenyl which may be substituted by one or two halogen, 1-3 C alkyl, 1-3 C alkoxy or nitro; or n X2 together with R4 is ##STR3## where n is 1 or 2; m is 0 or 1; X is hydrogen, halogen, 1-3 C alkyl, 1-3 C alkoxy or nitro; and n X3 is hydrogen or --CO--R4 where R4 is hydrogen, 1-6 alkyl, 1-6 C haloalkyl, 3-6 C cycloalkyl, phenylalkyl(1-6C) or phenyl where the phenyl ring may be substituted by one or two halogen, 1-3 alkyl, 1-3 alkoxy or nitro; and n X4 is --OH, fluorine, OCOAlkyl(1-4C), --O--trialkyl(1-6C)silyl, --O--tetrahydropyranyl, --O--tetrahydrofuranyl or --O--SO 2 R 6 where R6 is methyl, trifluoromethyl, phenyl or p-methyl-phenylprovided, however, that X4 is not OH when R is a nitro group; n for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives. |