| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79bbba2bc92788a92fc993d3300340e8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2984 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11D17-0026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11D17-0021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C11D17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
1989-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1992-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8f23b0be2c069d9e1e4f2c801098089 |
| publicationDate |
1992-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5104736-A |
| titleOfInvention |
Reinforced paucilamellar lipid vesicles |
| abstract |
Disclosed are paucilamellar lipid vesicles reinforced with polyacrylamide, and methods of producing the same. The vesicles include about 2-10 lipid bilayers in the form of substantially spherical shells separated by a plurality of aqueous layers. Each of the bilayers have a layer of polyacrylamide lining its innermost side. The bilayers and the aqueous layers surround a large, substantially amorphous central cavity containing a water-immiscible oily phase or a polyacrylamide core. The method of the invention includes forming a lipophilic phase containing a surfactant and a lipid-soluble material to be encapsulated or to be incorporated into the lipid structure of the vesicle, forming an aqueous phase containing polyacrylamide; shear mixing the lipophilic phase and the aqueous phase, thereby forming a plurality of paucilamellar lipid vesicles containing acrylamide in their aqueous regions; separating the vesicles from any unincorporated vesicle constituents; and polymerizing the acrylamide in the aqueous layers of the vesicles. A method of encapsulating a water-soluble material is also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5762904-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008045575-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034796-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5670099-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6004534-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8889398-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361990-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010137437-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5219538-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5547677-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5464629-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5846551-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008020997-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6387397-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004087564-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010209494-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10251839-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021236394-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6039960-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6506262-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011135716-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010172831-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6280753-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2939313-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2213283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5626870-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6060082-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009186074-A1 |
| priorityDate |
1988-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |