| abstract |
The subject of the invention is peptide derivatives corresponding to formula n n X.sup.1 - X.sup.2 - Gly - Asp-X.sup.3 - X.sup.4 (I) n n in which: n X 1 represents a hydrogen atom, a N-protecting group, an amino acid residue or a N-protected amino acid residue, n X 2 represents a residue of L-Arg or D-Arg, L-Orn or D-Orn, N-aminocarbonyl -L-Orn or N-aminocarbonyl-D-Orn, or L-Lys, or D-Lys, n X 3 represents a residue of L-Trp, D-Trp, L-Leu, D-Leu, L-Ile, D-Ile, L-Phe, D-Phe or a chain of 2 or 3 of these residues, and n X 4 represents a -OH group, -NH 2 group, -OR 1 group in which R 1 represents an alkyl radical of C 1 to C 4 , a NHR 2 group in which R 2 represents an alkyl radical of C 1 to C 4 , or an amino acid residue. n These derivatives are useful in therapy on account of their platelet aggregation inhibiting activity. |