| abstract |
Imidazole derivatives of the formula: ##STR1## wherein R 1 , R 2 , R' 1 and R' 2 which can be the same or different, are H, CH 3 , C 2 H 5 , OCH 3 , OH, CH 2 OH, NH 2 or halogen; R' if H or ##STR2## where R 3 is H, CH 3 , or halogen; R 4 is H and R 5 is H or OH and R 6 is H or OH or one of R 5 and R 6 is H and the other, together with R 4 , forms a bond and X and Y, which can be the same or different, are a bond, a straight C 1-2 -alkyl or the corresponding alkenyl, and pharmaceutically acceptable salts thereof exhibit valuable pharmacological properties, especially aromatase inhibiting effects and are useful in the treatment of estrogen dependent diseases, e.g. breast cancer. Anti-mycotic and antifungal properties have also been found. |